Table 1 Cardiac hypertrophy in HCM mice a
From: Mice Expressing Mutant Myosin Heavy Chains Are a Model for Familial Hypertrophic Cardiomyopathy
Heart (mg) | Atria (mg) | RV (mg) | LV (mg) | Body (g) | Tibial Length (mm) | |
|---|---|---|---|---|---|---|
A. Heart and Chamber Weights, Female Mice 12 weeks Control (n = 16) | 99.6 ± 4.4 | 5.2 ± 0.6 | 19.1 ± 1.4 | 68.8 ± 3.7 | 22.2 ± 1.3 | 16.9 ± 0.2 |
131 line (n = 8) | 94.3 ± 5.8a | 4.3 ± 1.0a | 18.5 ± 1.0a | 65.0 ± 5.3a | 21.1 ± 1.0a | 16.8 ± 0.3 |
140 line (n = 9) | 114.4 ± 12.4a | 5.2 ± 0.6 | 21.8 ± 2.1b | 76.9 ± 8.7b | 22.0 ± 1.1 | 16.7 ± 0.4 |
8 months Control (n = 8) | 96.6 ± 2.9 | 4.5 ± 0.7 | 17.5 ± 1.3 | 66.8 ± 3.9 | 22.6 ± 2.1 | 17.3 ± 0.4 |
131 line (n = 10) | 104.4 ± 10.9a | 4.8 ± 1.1 | 17.6 ± 2.0 | 73.0 ± 8.7 | 24.9 ± 2.7 | 18.1 ± 0.8a |
140 line (n = 16) | 125.8 ± 14.9b | 5.2 ± 1.0 | 23.3 ± 3.5b | 88.4 ± 9.8b | 28.0 ± 3.0b | 17.7 ± 0.4b |
B. Heart and Chamber Weights, Male Mice 12 weeks Control (n = 13) | 111.0 ± 5.5 | 5.8 ± 0.6 | 22.1 ± 1.6 | 74.7 ± 4.2 | 26.2 ± 1.0 | 17.2 ± 0.3 |
131 line (n = 9) | 109.5 ± 5.7 | 5.0 ± 0.8a | 21.8 ± 2.3 | 74.1 ± 3.2 | 25.6 ± 1.9 | 16.9 ± 0.2 |
140 line (n = 7) | 119.0 ± 6.7a | 5.9 ± 1.3 | 24.1 ± 1.8a | 79.8 ± 4.6a | 25.6 ± 1.5 | 17.0 ± 0.2 |
8 months Control (n = 7) | 153.8 ± 26.9 | 7.6 ± 2.6 | 27.4 ± 5.9 | 107.3 ± 19.0 | 33.2 ± 4.9 | 17.8 ± 0.3 |
131 line (n = 8) | 138.1 ± 16.8 | 6.4 ± 1.0 | 24.5 ± 3.6 | 98.6 ± 14.0 | 31.2 ± 3.8 | 17.7 ± 0.2 |
140 line (n = 7) | 161.4 ± 15.4 | 7.2 ± 2.1 | 27.4 ± 3.3 | 116.0 ± 11.9 | 33.5 ± 3.9 | 17.5 ± 0.3 |