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Table 1 Cardiac hypertrophy in HCM mice a

From: Mice Expressing Mutant Myosin Heavy Chains Are a Model for Familial Hypertrophic Cardiomyopathy

  Heart (mg) Atria (mg) RV (mg) LV (mg) Body (g) Tibial Length (mm)
A. Heart and Chamber Weights, Female Mice 12 weeks Control (n = 16) 99.6 ± 4.4 5.2 ± 0.6 19.1 ± 1.4 68.8 ± 3.7 22.2 ± 1.3 16.9 ± 0.2
131 line (n = 8) 94.3 ± 5.8a 4.3 ± 1.0a 18.5 ± 1.0a 65.0 ± 5.3a 21.1 ± 1.0a 16.8 ± 0.3
140 line (n = 9) 114.4 ± 12.4a 5.2 ± 0.6 21.8 ± 2.1b 76.9 ± 8.7b 22.0 ± 1.1 16.7 ± 0.4
8 months Control (n = 8) 96.6 ± 2.9 4.5 ± 0.7 17.5 ± 1.3 66.8 ± 3.9 22.6 ± 2.1 17.3 ± 0.4
131 line (n = 10) 104.4 ± 10.9a 4.8 ± 1.1 17.6 ± 2.0 73.0 ± 8.7 24.9 ± 2.7 18.1 ± 0.8a
140 line (n = 16) 125.8 ± 14.9b 5.2 ± 1.0 23.3 ± 3.5b 88.4 ± 9.8b 28.0 ± 3.0b 17.7 ± 0.4b
B. Heart and Chamber Weights, Male Mice 12 weeks Control (n = 13) 111.0 ± 5.5 5.8 ± 0.6 22.1 ± 1.6 74.7 ± 4.2 26.2 ± 1.0 17.2 ± 0.3
131 line (n = 9) 109.5 ± 5.7 5.0 ± 0.8a 21.8 ± 2.3 74.1 ± 3.2 25.6 ± 1.9 16.9 ± 0.2
140 line (n = 7) 119.0 ± 6.7a 5.9 ± 1.3 24.1 ± 1.8a 79.8 ± 4.6a 25.6 ± 1.5 17.0 ± 0.2
8 months Control (n = 7) 153.8 ± 26.9 7.6 ± 2.6 27.4 ± 5.9 107.3 ± 19.0 33.2 ± 4.9 17.8 ± 0.3
131 line (n = 8) 138.1 ± 16.8 6.4 ± 1.0 24.5 ± 3.6 98.6 ± 14.0 31.2 ± 3.8 17.7 ± 0.2
140 line (n = 7) 161.4 ± 15.4 7.2 ± 2.1 27.4 ± 3.3 116.0 ± 11.9 33.5 ± 3.9 17.5 ± 0.3
  1. aValues ± SD.
  2. bp < 0.05.
  3. cp < 0.005.