Fig. 1
From: Tissue Distribution and Regulation of Plasminogen Activator Inhibitor-1 in Obese Mice
PAI-1 activity in the plasma from obese (ob/ob) and lean (+/?) mice
Plasma was collected from 4-, 8-, and 12-week-old lean (○) and obese (●) mice (six animals for each age), and the concentration of active PAI-1 (ng/ml) was determined using the t-PA binding assay as described in Materials and Methods. Four weeks, mean = 20.3 ± 1.4; 8 weeks, mean = 24.2 ± 2.1; 12 weeks, mean = 30.0 ± 4 (n = 6 ± SD). Between 4 and 8 weeks, p < 0.001; 8 and 12 weeks, p < 0.01; 4 and 12 weeks, p < 0.0003 (unpaired t test).