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Fig. 8 | Molecular Medicine

Fig. 8

From: Aspirin-Triggered Lipoxins (15-epi-LX) Are Generated by the Human Lung Adenocarcinoma Cell Line (A549)–Neutrophil Interactions and Are Potent Inhibitors of Cell Proliferation

Fig. 8

Proposed scheme for generating 15-epi-LXs

ASA-acetylated PGHS-2 and/or P450 activities contribute to 15R-HETE generation. Epithelial-derived 15R-HETE undergoes transcellular conversion by leukocyte 5-LO to a 15-epi-5(6)-epoxytetraene intermediate, which is common to both 15-epi-LXA4 and 15-epi-LXB4. The complete stereochemistry of 15-epi-LXA4 has been determined (4), and the stereochemical assignment of 15-epi-LXB4 is tentative.

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