|
Compound (10
−7
M)
|
% Inhibition
|
p
Value
a
|
|---|
|
Vehicle
|
1.6 ± 10.3
|
NS
|
|
LXA4
|
16.3 ± 5.2
|
NS
|
|
15-epi-LXA4
|
20.1 ± 1.9
|
<0.025
|
|
LXB4
|
34.0 ± 8.5
|
<0.005
|
|
15-epi-LXB4
|
79.3 ± 0.3
|
<0.001*
|
|
Dexamethasone
|
42.1 ± 5.4
|
<0.005
|
|
15S-HETE
|
10.0 ± 8.0
|
NS
|
|
15R-HETE
|
16.8 ± 11.5
|
NS
|
- Cells (2000 A549 cells/well) were grown in 96-well plates and exposed to vehicle (0.15% v/v in EtOH/F-12K media) or equimolar concentrations (10−7 M) of LXA4, 15-epi-LXA4, LXB4, 15-epi-LXB4, or dexamethasone for 72 hr at 37°C. Values represent mean ± SEM from three to seven experiments performed in quadruplicate and are expressed as percentage inhibition of cell growth.
- ap values denote statistical differences compared with cells alone.
- bp < 0.001 for 15-epi-LXB4 compared with LXB4.
