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Table 1 LX and 15-epi-LX actions on cell proliferation

From: Aspirin-Triggered Lipoxins (15-epi-LX) Are Generated by the Human Lung Adenocarcinoma Cell Line (A549)–Neutrophil Interactions and Are Potent Inhibitors of Cell Proliferation

Compound (10 −7 M)

% Inhibition

p Value a

Vehicle

1.6 ± 10.3

NS

LXA4

16.3 ± 5.2

NS

15-epi-LXA4

20.1 ± 1.9

<0.025

LXB4

34.0 ± 8.5

<0.005

15-epi-LXB4

79.3 ± 0.3

<0.001*

Dexamethasone

42.1 ± 5.4

<0.005

15S-HETE

10.0 ± 8.0

NS

15R-HETE

16.8 ± 11.5

NS

  1. Cells (2000 A549 cells/well) were grown in 96-well plates and exposed to vehicle (0.15% v/v in EtOH/F-12K media) or equimolar concentrations (10−7 M) of LXA4, 15-epi-LXA4, LXB4, 15-epi-LXB4, or dexamethasone for 72 hr at 37°C. Values represent mean ± SEM from three to seven experiments performed in quadruplicate and are expressed as percentage inhibition of cell growth.
  2. ap values denote statistical differences compared with cells alone.
  3. bp < 0.001 for 15-epi-LXB4 compared with LXB4.
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Molecular Medicine

ISSN: 1528-3658