Fig. 6

Putative mechanism of action of the hGR β isoform

hGRβ, like unliganded hGRα, is anchored to hsp90 as part of a cytoplasmic heterooligomer. In the presence of glucocorticoid, hGRβ heterodimerizes with ligand-bound GRα and translocates into the nucleus as a heterodimer. There, it interacts with GREs and acts as a dominant negative inhibitor of the classic receptor, decreasing the effects of glucocorticoids on modulating gene transcription.