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Fig. 2 | Molecular Medicine

Fig. 2

From: The Repertoire of CD4+ CD28 T Cells in Rheumatoid Arthritis

Fig. 2

TCR BV gene segment usage in CD4 + CD28 T cells

Five normal individuals and 10 RA patients were identified who had more than 2.5% of CD4+ CD28 T cells (Fig. 1). PBMC were analyzed by three-color FACS analysis with PercP-anti-CD4, PE-anti-CD28, and FITC-anti-BV element. Compared with the CD4+ CD28+ compartment (), the TCR β-chain repertoire of CD4+ CD28 T cells (■) was strongly skewed toward the preferential usage of few BV elements. Three representative individuals are shown; results for all normal individuals and RA patients are summarized in Table 1.

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