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Fig. 4 | Molecular Medicine

Fig. 4

From: The Repertoire of CD4+ CD28 T Cells in Rheumatoid Arthritis

Fig. 4

Diversity of CD4 + CD28 T cells

To examine the question of whether the repertoire of CD4+ CD28 T cells is generally restricted or whether few T cell clones have emerged from a polyclonal repertoire, TCR sequences sharing selected BV elements were reamplified with BV- and BJ-specific primers and size-fractionated. Results are shown for BV18-BJ combinations from the same patient, all of which had a Gaussian distribution of band intensities, suggesting polyclonality. No additional dominant clonotype was identified at the more sensitive resolution level, indicating that the CD4+ CD28 T cell compartment is primarily polyclonal with the emergence of single clonotypes.

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