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Fig. 4 | Molecular Medicine

Fig. 4

From: Inherited Resistance to HIV-1 Conferred by an Inactivating Mutation in CC Chemokine Receptor 5: Studies in Populations with Contrasting Clinical Phenotypes, Defined Racial Background, and Quantified Risk

Fig. 4

Distribution of CCR5 genotypes by the degree of exposure to HIV-1 among highly exposed-seronegative homosexuals

(A) Distribution of risk for all seronegative MACS participants (n = 2430 as of 10/96). Risk score is the number of anal receptive intercourse (ARI) partners over 2.5 years prior to MACS visit #2 (24). The dotted vertical line demarcates the boundary between the top 10th and bottom 90th percentiles of risk. The distribution of risk for seropositive MACS participants did not differ significantly from that shown for seronegative MACS participants (not shown). (B) Distribution of CCR5 genotypes among highly exposed-seronegative MACS participants. CCR5 genotypes are coded as follows: 1/1, CCR5-1 homozygote; 1/2, CCR5-1/CCR5-2 heterozygote; 2/2, CCR5-2 homozygote. The dotted horizontal line demarcates the boundary between the top 10th and bottom 90th percentiles. Each symbol corresponds to a single seronegative MACS participant with the corresponding genotype and risk score. Open symbols, individuals previously reported to be transiently infected with HIV-1 (25).

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