Inherited Resistance to HIV-1 Conferred by an Inactivating Mutation in CC Chemokine Receptor 5: Studies in Populations with Contrasting Clinical Phenotypes, Defined Racial Background, and Quantified Risk

Table 1 Genotypic distribution of wild-type and mutant CCR5 alleles in different racial groups within general and HIV-1 exposed populations

HIV-1 Phenotype	Region/Race^a	n	Genotypic Totals^b
HIV-1 Phenotype	Region/Race^a	n	1/1	(%)	1/2	(%)	2/2	(%)
Random blood donors	NA/Caucasians	387	300	(77.5)	84	(21.7)	3	(0.8)
	NA/Blacks	294	277	(94.2)	17	(5.8)	0	(0.0)
	NA/Hispanics	290	269	(92.8)	20	(6.9)	1	(0.3)
	NA/Asians	164	163	(99.4)	1	(0.6)	0	(0.0)
	NA/Native Americans	87	73	(83.9)	11	(12.6)	3	(3.4)
	WA/Blacks	40	40	(100.0)	0	(0.0)	0	(0.0)
	India Tamils	46	46	(100.0)	0	(0.0)	0	(0.0)
	Totals	1308	1168		133		7
HIV-1+	NA/Caucasians	614	475	(77.4)	139	(22.6)	0	(0.0)
	NA/Blacks	86	84	(97.7)	2	(2.3)	0	(0.0)
	NA/Hispanics	45	42	(93.3)	3	(6.7)	0	(0.0)
	Totals	745	601		144		0
HIV-1 exposed/uninfected	NA/Caucasians	111	82	(73.9)	24	(21.6)	5	(4.5)
	NA/Blacks	2	1	(50.0)	1	(50.0)	0	(0.0)
	NA/Hispanics	12	11	(91.7)	1	(8.3)	0	(0.0)
	Totals	125	94		26		5

^aNA = North America; WA = West Africa.
^b1/1 = CCR5-1 (wild-type allele) homozygotes; 1/2 = CCR5-1/CCR5-2 heterozygotes; 2/2 = CCR5-2 (deleted allele) homozygotes.

ISSN: 1528-3658