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Table 2 Comparison of CCR5 genotypic distribution among general and HIV-1 exposed Caucasian populations

From: Inherited Resistance to HIV-1 Conferred by an Inactivating Mutation in CC Chemokine Receptor 5: Studies in Populations with Contrasting Clinical Phenotypes, Defined Racial Background, and Quantified Risk

HIV-1 Phenotypes

x 2

d.f.

ap-value ≅

EU vs. HIV-1 +

27.85

2

<0.0001

EU vs. Normals

7.62

2

0.022

HIV-1+ vs. Normals

4.85

2

0.088

LTNP vs. HIV-1 +

7.42

1

0.006

LTNP(a) vs. LTNP(b)b

0.0015

1

0.969

  1. EU = HIV-1 exposed/uninfected individuals; Normals = random blood donors; LTNP = long-term nonprogressors; d.f. = degrees of freedom.
  2. a≅=p-values are uncorrected. Application of Bonferroni correction factor would multiply all p-values by 5 accounting for the 5 comparisons performed.
  3. bLTNP (a) was obtained from MACS (n = 53); LTNP(b) was obtained from LIR/NIAID (n = 32).
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Molecular Medicine

ISSN: 1528-3658