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Table 3 CCR5 genotypes in sets of matched a seropositive Caucasians exhibiting discordant rates of disease progression

From: Inherited Resistance to HIV-1 Conferred by an Inactivating Mutation in CC Chemokine Receptor 5: Studies in Populations with Contrasting Clinical Phenotypes, Defined Racial Background, and Quantified Risk

Genotype Combinations within Matched Triplets Rb

Rb

M

L

n≅c

%d

1/1

1/1

1/2

8

(16.7)

1/1

1/2

1/2

4

(8.3)

1/2

1/2

1/2

1

(2.1)

1/2

1/1

1/2

4

(8.3)

1/1

1/2

1/1

3

(6.3)

1/1

1/1

1/1

20

(41.7)

1/2

1/1

1/1

5

(10.4)

1/2

1/2

1/1

3

(6.3)

   

48

(100.0)

  1. aSeropositive MACS participants concordant for multiple clinical criteria but discordant for rate of progression to AIDS (22).
  2. bR = rapid; M = moderately rapid; L = long-term nonprogressor as defined by the rate of CD4+ leukocyte change (22).
  3. c≅ n = number of triplets exhibiting CCR5 genotype combination.
  4. d% = percentage of triplets exhibiting CCR5 genotype combination.
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Molecular Medicine

ISSN: 1528-3658