From: CD3-ε Overexpressed in Prothymocytes Acts as an Oncogene
Construct | Transgenic Mouse Line | Copy No. of Transgenea | Thymocyte (% of wt)b | % of Mice with Tumors after 8 monthsc | ||
---|---|---|---|---|---|---|
+/+ | +/− | +/+ | +/− | |||
ε | 26 | 30–35 | 1 | 11 | 0 | 82 |
εΔ1 | 2978 | 40–45 | 2 | 16 | 0 | 62 |
2966H | 20–25 | 13 | 42 | 50 | 15 | |
2966L | 3–5 | wt | wt | 0 | 0 | |
εΔ2 | 2982 | 40–45 | wt | wt | 0 | 0 |
2994H | 20–25 | wt | wt | 0 | 0 | |
ε m | 2270 | 20–25 | 5 | 37 | 0 | 52 |
2285 | 20–25 | 13 | 42 | n.d. | 29 | |
2273 | 15–20 | 26 | 74 | n.d. | 25 | |
2279 | 10–15 | 41 | wt | 20 | 0 |