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Fig. 1 | Molecular Medicine

Fig. 1

From: An Islet-Cell Protein Tyrosine Phosphatase Is a Likely Precursor to the 37-kDa Autoantigen in Type 1 Diabetes: Human and Macaque Sequences, Tissue Distribution, Unique and Shared Epitopes, and Predictive Autoantibodies

Fig. 1

Cloning strategy, macaque and human sequences, and homology to ICA512/IA2

(A) Cloning strategy for macaque (M, top 7 sequences) and human (H, bottom 4 sequences) M1851. Specific products described in the text are indicated by numbers to the right in the figure. (B) The 3,042-nucleotide cDNA sequence and 1,014 amino acid primary structure of macaque islet M1851. A partial sequence (2,456 nucleotides) from human M1851 is also aligned. The 11-residue tyrosine phosphatase core sequence, the 25-residue transmembrane region, an extracellular tribasic site (RKK) and an asparagine glycosylation site (NVTT) of possible posttranslational processing, and the 18-residue signal peptide, are underlined. Asterisks are placed above differences between human and macaque nucleotide sequences, and human amino acids differing from the macaque sequence are noted directly below the corresponding macaque residue. (C) Homology between human ICA512 and human/macaque M1851 proteins. Both identical and conservative changes are allowed. The graph shows homology over a 25-residue window. The horizontal line represents 50% homology.

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Molecular Medicine

ISSN: 1528-3658