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Fig. 5 | Molecular Medicine

Fig. 5

From: An Islet-Cell Protein Tyrosine Phosphatase Is a Likely Precursor to the 37-kDa Autoantigen in Type 1 Diabetes: Human and Macaque Sequences, Tissue Distribution, Unique and Shared Epitopes, and Predictive Autoantibodies

Fig. 5

Recombinant icM1851 autoantibody assay in diabetes and prediabetes

Left: Indices representing relative levels of autoantibodies to recombinant intracellular M1851 (icM1851), which were positive in 56/183 new IDDM patients, 28/60 first-degree relatives later progressing to clinical diabetes, and 1/91 healthy control subjects. The dotted line represents the cutoff for positivity, which is an index of 0.04. Right: Comparison of the prevalence of autoantibodies to GAD and to M1851 versus sampling time before the diagnosis of IDDM. Numbers of subjects in each time range are shown at the bottom of the panel.

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