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Fig. 6 | Molecular Medicine

Fig. 6

From: An Islet-Cell Protein Tyrosine Phosphatase Is a Likely Precursor to the 37-kDa Autoantigen in Type 1 Diabetes: Human and Macaque Sequences, Tissue Distribution, Unique and Shared Epitopes, and Predictive Autoantibodies

Fig. 6

Comparison of autoantibody epitopes between M1851 and ICA512

Left: Direct comparison of autoantibody indices to icM1851 versus icICA512. Right: Competition of binding of radiolabeled icM1851 by unlabeled recombinant icICA512. For 53 IDDM sera recognizing icM1851, icM1851ab index without competitor is plotted versus the same index in the presence of excess unlabelled icICA512. Reactivity was fully blocked in 29/53 sera (open symbols), while 24/53 retained partial ability to bind icM1851 (filled symbols). In both panels, the dotted line denotes equal indices.

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Molecular Medicine

ISSN: 1528-3658