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Fig. 1 | Molecular Medicine

Fig. 1

From: Expression of Molecular Biomarkers in Primary Breast Tumors Implanted into a Surrogate Host: Increased Levels of Cyclins Correlate with Tumor Progression

Fig. 1

Immunohistochemical detection of cyclins D1 and D3, estrogen receptor, p53, and c-erbB-2 in T 0 and T 1 tumors

Representative sections (neg. T0) are illustrated from T0 tumor 118, which were undetectable for cyclins D1 and D3, and undetectable for estrogen receptor; sections from tumor 089 were undetectable for p53, and tumor 062 exhibited 13% positive cell staining for c-erbB-2. Tissue sections from the ductal carcinoma T0 tumor 195 are shown representing positive (pos. T0) staining to all the antigens. The staining patterns of tissue sections from tumor 195 (pos. T1) show staining patterns similar to that observed in the T0 tumor. Notice the strong nuclear staining of cells positive for cyclins D1 and D3, estrogen receptor, and p53, and membrane-specific staining for c-erbB-2 protein. D1, cyclin D1; D3, cyclin D3; ER, estrogen receptor; erb, c-erbB-2; neg., negative; pos., positive.

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Molecular Medicine

ISSN: 1528-3658