Fig. 3
From: The Role of a Single Formin Isoform in the Limb and Renal Phenotypes of Limb Deformity
Analysis of mutant mice
(A) and (B) Forelimbs after skeletal staining. Note that both limbs have the normal number of digits, and both have paired long bones (radius and ulna). Left, ldGKO/+ limb; right, ldGKO/ldGKO limb. (C) ldGKO/ldGKO animal with bilateral renal agenesis. The adrenal glands (a) were present bilaterally, but the ureter (ur) was present only on the left side. (D) ldGKO/ldGKO animal with unilateral (left) renal agenesis. The adrenal glands (a) were present bilaterally, but the ureter (ur) was present only on the side with the kidney (k) and distinguished from the uterine horn (uh) on the same side. (E) Kidney from a 2-week-old + / + mouse, sectioned and stained with hematoxylin and eosin. (F) Kidney from a ldGKO/ldln2 2-week-old littermate with bilateral multicystic dysplastic kidneys, sectioned and stained with hematoxylin and eosin. Note the massive cysts, due to maldevelopment of the excretory system. (G) Part of kidney section in F (higher magnification). The small cysts on the right of the figure reflect the maldevelopment associated with the multicystic dysplastic kidney phenotype.