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Fig. 1 | Molecular Medicine

Fig. 1

From: Degradation of C1-Inhibitor by Plasmin: Implications for the Control of Inflammatory Processes

Fig. 1

C1-Inh consumption in plasma of a normal individual and of patients with the inflammatory conditions SLE, ARDS, and RA and in the synovial fluid of a patient with RA

C1-Inh consumption and degradation was visualized by immunoblotting for C1-Inh which revealed native (115 kDa), cleaved (96 and 83 kDa), and complexed C1-lnh (225 and 209 kDa): normal plasma (lane 1); SLE plasma (lane 2); ARDS plasma (lane 3); RA plasma (lane 4); RA synovial fluid (lane 5). Native, cleaved, and complexed C1-Inh were scanned and quantified by densitometry. Lanes 2–5 represent samples with relatively large amounts of cleaved or complexed C1-Inh.

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