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Fig. 1 | Molecular Medicine

Fig. 1

From: Inhibition of Astrocyte Glutamate Uptake by Reactive Oxygen Species: Role of Antioxidant Enzymes

Fig. 1

Concentration-dependent inhibition by hydrogen peroxide and peroxynitrite of Glu uptake: potentiation by copper ions and ascorbate

(A) H2O2, CuSO4 (25 µM), and ascorbate (100 µM) were added 10 min before incubation with 3H-Glu. (B) Peroxynitrite was added immediately after addition of the 3H-Glu solution. The symbols and indicate the uptake levels for the curves of H2O2 alone and H2O2 + CuSO4 + ascorbate, respectively (A).

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