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Table 2 Hydrogen peroxide-induced inhibition of glutamate uptake: effect of glutathione peroxidase inhibitors

From: Inhibition of Astrocyte Glutamate Uptake by Reactive Oxygen Species: Role of Antioxidant Enzymes

H2O2 (mM)

MSA (mM)

NEM (mM)

Glutamate Uptake (% of Basal)

0

0

0

100 ± 2

0.5

0

0

34 ± 3**

0.5

0.1

0

36 ± 2**a

0

1

0

108 ± 5

0.5

1

0

35 ± 1**a

0

0

0.25

65 ± 5**

0.5

0

0.25

17 ± 1**b

  1. MSA was added 4 hr, H2O2 and NEM 10 min before incubation with 3H-glutamate.
  2. aNot significantly different from H2O2 alone (p > 0.05).
  3. bSignificantly different from H2O2 alone (p < 0.01).
  4. **p < 0.01.