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Table 4 Effect of NO and NO donors on glutamate uptake

From: Inhibition of Astrocyte Glutamate Uptake by Reactive Oxygen Species: Role of Antioxidant Enzymes

Reagent (% of Control)

Glutamate Uptake

H2O2 0.2 mM

66 ± 5**

H2O2 2 mM

39 ± 1**

NO

91 ± 5

SNP 0.1 mM

103 ± 6

SNP 1 mM

96 ± 5

SNAP 0.25 mM

98 ± 3

SNAP 1 mM

100 ± 3

  1. All reagents were added immediately before addition of
  2. 3H-glutamate.
  3. **p < 0.01.
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Molecular Medicine

ISSN: 1528-3658