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Fig. 2 | Molecular Medicine

Fig. 2

From: Chondroitin-4-Sulfate Impairs In Vitro and In Vivo Cytoadherence of Plasmodium falciparum Infected Erythrocytes

Fig. 2

Selection of IRBCs exhibiting CSA-mediated cytoadherence

Palo-Alto initial IRBC population was selected by panning on SBEC 17 and the cytoadherence phenotype of the selected IRBCs was investigated through a cytoadherence inhibition assay on 1D cells. The cytoadherence inhibitions by 100 µg/ml of soluble CSA, pretreatment of 1D cells with 1 U/ml of chondroitinase ABC (Case ABC) during 1 hr, 5 µg/ml of anti-CD36 monoclonal FA6-152 antibody, and 25 µg/ml of anti-ICAM-1 monoclonal 84H10 antibody are expressed as the percentage of the control (5855 ± 57 cytoadherent IRBC/mm2) in the absence of glycosaminoglycan or chondroitinase ABC treatment, or in the presence of unrelated mouse IgG1 antibody.

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