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Fig. 4 | Molecular Medicine

Fig. 4

From: Chondroitin-4-Sulfate Impairs In Vitro and In Vivo Cytoadherence of Plasmodium falciparum Infected Erythrocytes

Fig. 4

Cytoadherence inhibitory activity of sera collected from CSA-treated Saimiri monkeys

In vitro inhibition of cytoadherence to C2 SBECs was performed with Palo-Alto IRBCs selected on SBEC 17 monolayers. Sera were obtained from four monkeys which were injected intramuscularly with CSA dissolved in NaCl 0.9% (50 mg/kg body weight). Results are presented for serum samples collected immediately before time 0 and 0.5, 1, 2, 4, and 8 hr (Monkey 89009), 1, 4, 16, and 32 hr (Monkeys 1465 and 1748), or 0.5, 2, 8, and 32 hr (Monkey 0716) after the CSA injection. They are expressed as the percentage of cytoadherence at time 0; the IRBC cytoadherence/mm2 of confluent C2 cells is given for each animal at time 0.

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