Chondroitin-4-Sulfate Impairs In Vitro and In Vivo Cytoadherence of Plasmodium falciparum Infected Erythrocytes

Table 1 SBECs express different combinations of surface IRBC cytoadherence receptors

SBEC	CSA	TM	CD44	CD36	ICAM-1
ID	+	+	+	+	+
3A	+	+	−	−	+
C2	+	+	−	+	−
17	+	+	+	−	−

FACScan and IF analysis of SBECs, C32, and CHO transfectants. Presence (+) or absence (−) of the different receptors were detected by anti-CD36 (OKM5), anti-ICAM-1 (84H10), anti-CSA (MAB2030), anti-CD44 (J-173), and polyclonal sheep anti-thrombomodulin antibodies directed against the core protein of thrombomodulin. These cells were also consistently positive, at different degrees, for endothelial cell nitric oxide synthase when assayed by indirect immunofluorescence (with mAb N30020 from Transduction Laboratories, Lexington, KY) (data not shown).

ISSN: 1528-3658