Giant Cell Vasculitis Is a T Cell-Dependent Disease

Table 3 TCR β-chain sequences of T cell clones with identical sequences retrieved from independent mice implanted with temporal artery tissue from the same patient

Patient			BV					N-D-N						BJ
GCA-1 BV2	TCT	GCC	AGC	AGT	AGA	GGG	GCA	GGA	GGA		ACA	GAT	ACG	CAG	TAT	TTT	BJ2S3	2 of 3^a
	C	A	S	S	R	G	A	G	G		T	D	T	Q	Y	F
BV5S2	TCT	GCC	AGC	AGT	TTG	CCG	GCT	AGC	GGT	ACT		GAT	ACG	CAG	TAT	TTT	BJ2S3	2 of 5
	C	A	S	S	L	P	A	S	G	T		D	T	Q	Y	F
BV13	TCT	GCC	AGC	AGT	TTA	CTA	CAG	CGA			AAA	AAC	ATT	CAG	TAC	TTC	BJ2S4	2 of 3
	C	A	S	S	L	L	Q	R			K	N	I	Q	Y	F
BV17	TCT	GCC	AGC	AGT	ATC	TTC	CCT	GGG	ACA	GGG
	C	A	S	S	I	F	P	G	T	G
					GGC	ATG	ACT	AGT	TAC	GAT				GAG	CAG	TTC	BJ2S1	2 of 3^a
					G	M	T	S	Y	D				E	Q	F
BV17	TCT	GCC	AGC	AGT	GCA	AGG	GAC	AGG	CGG			GAG	ACC	CAG	TAC	TTC	BJ2S5	2 of 3
	C	A	S	S	A	R	D	R	R			E	T	C	Y	F
GCA-2 BV2	TCT	GCC	AGC		ACG	GTG	GCA	GGG	AAT		AAT	TCA	CCC	CTC	CAC	TTT	BJ1S6	3 of 4
	C	A	S		T	V	A	G	N		N	S	P	L	H	F
BV8	TCT	GCC	AGC	AGT	TAC	CTG	ACA	GGG	TTA	GAC		ACT	GAA	GCT	TCC	TTT	BJ1S1	2 of 4
	C	A	S	S	Y	L	T	G	L	D		T	E	A	F	F
BV8	TCT	GCC	AGC	AGT	TTA	TTG	GGA	CAG	AGG	ATC			CCC	CAG	CAT	TTT	BJ1S5	2 of 4^a
	C	A	S	S	L	L	G	Q	R	I			P	Q	H	F
GCA-3 BV2	TCT	GCC	AGC		CCT	AGG	GCC					AAT	GAG	CAG	TTC	TTC	BJ2S1	2 of 4
	C	A	S		P	R	A					N	E	Q	F	F
BV5S2	TCT	GCC	AGC	AGT	ATC	TCG	GGA	GAC	ACT	CCG	ACA	GAT	ACG	CAG	TAT	TTT	BJ2S3	3 of 4
	C	A	S	S	I	S	G	D	T	P	T	D	T	Q	Y	F
BV17	TCT	GCC	AGC	AGT	ACC	TTG	ACA	GGG	ACA	GGA		TCA	CCC	CTC	CAC	TTT	BJ1S6	2 of 4
	C	A	S	S	T	L	T	G	T	G		S	P	L	H	F
GCA-6 BV5S2	TCT	GCC	AGC		AGT	GTG	GGG	GCT	TCA	GGA				GCT	TCC	TTT	BJ1S1	4 of 4^a
	C	A	S		S	V	G	A	S	G				A	F	F
^aTCR sequence was also found in the pre-implanted tissue, albeit at a lower frequency.

ISSN: 1528-3658