Fig. 5
From: TNF-α Opens a Paracellular Route for HIV-1 Invasion across the Blood-Brain Barrier
Brain endothelial cells but not astrocytes or collagen I-fibronectin matrix provide a barrier to HIV-1
HIV-1 (50 pg of p24 antigen) was placed in the upper chamber of models prepared on a terephthalate membrane with no addition (open circles), collagen I and fibronectin matrix with astrocytes (open triangles), collagen I and fibronectin matrix with endothelial cells (closed squares), or collagen I and fibronectin matrix with endothelial cells and astrocytes (closed diamonds). The lower chamber samples were assayed by HIV-1 RNA assay.