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Table 3 Single locus sib-pair linkage results between melanocortin receptors 4 and 5 genes and obesity, and diabetes-related variables in the Québec Family Study

From: Linkage and Association Studies between the Melanocortin Receptors 4 and 5 Genes and Obesity-Related Phenotypes in the Québec Family Study

  MC5R/PstI MC5R/PvuII MC4R/NcoI
Variables N t p N t p N t p
BMI 255 −0.423 0.34 289 −3.041 0.001*** 258 −0.037 0.49
SF6 253 −0.103 0.46 287 −2.634 0.005* 256 0.166 0.57
FM 217 −0.306 0.38 242 −3.145 0.001*** 213 0.116 0.55
%FAT 217 −0.362 0.36 242 −2.184 0.02 213 0.195 0.58
FFM 217 −0.955 0.17 242 −2.423 0.008 213 −0.443 0.33
RMR 214 0.169 0.57 239 −2.928 0.002** 210 −1.087 0.14
RQ 214 −0.180 0.43 239 −0.042 0.48 210 −1.816 0.04
Glucose 217 0.888 0.81 242 −0.107 0.46 213 0.586 0.72
Glucose area 170 0.268 0.61 191 −0.458 0.32 160 2.232 0.99
Insulin 174 1.027 0.85 195 1.171 0.88 164 −0.208 0.42
Insulin area 163 −0.584 0.28 183 −0.375 0.35 153 −0.724 0.24
  1. Significant results at p ≤ 0.05 are highlighted in bold, and those remaining significant after the Bonferroni correction for multiple tests are indicated with asterisks. N, number of sib-pairs; t, t statistic from the linkage regression; p, probability values. See text for variables abbreviations.
  2. *p = 0.05; **p = 0.02; ***p = 0.01.
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Molecular Medicine

ISSN: 1528-3658