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Table 3 Single locus sib-pair linkage results between melanocortin receptors 4 and 5 genes and obesity, and diabetes-related variables in the Québec Family Study

From: Linkage and Association Studies between the Melanocortin Receptors 4 and 5 Genes and Obesity-Related Phenotypes in the Québec Family Study

 

MC5R/PstI

MC5R/PvuII

MC4R/NcoI

Variables

N

t

p

N

t

p

N

t

p

BMI

255

−0.423

0.34

289

−3.041

0.001***

258

−0.037

0.49

SF6

253

−0.103

0.46

287

−2.634

0.005*

256

0.166

0.57

FM

217

−0.306

0.38

242

−3.145

0.001***

213

0.116

0.55

%FAT

217

−0.362

0.36

242

−2.184

0.02

213

0.195

0.58

FFM

217

−0.955

0.17

242

−2.423

0.008

213

−0.443

0.33

RMR

214

0.169

0.57

239

−2.928

0.002**

210

−1.087

0.14

RQ

214

−0.180

0.43

239

−0.042

0.48

210

−1.816

0.04

Glucose

217

0.888

0.81

242

−0.107

0.46

213

0.586

0.72

Glucose area

170

0.268

0.61

191

−0.458

0.32

160

2.232

0.99

Insulin

174

1.027

0.85

195

1.171

0.88

164

−0.208

0.42

Insulin area

163

−0.584

0.28

183

−0.375

0.35

153

−0.724

0.24

  1. Significant results at p ≤ 0.05 are highlighted in bold, and those remaining significant after the Bonferroni correction for multiple tests are indicated with asterisks. N, number of sib-pairs; t, t statistic from the linkage regression; p, probability values. See text for variables abbreviations.
  2. *p = 0.05; **p = 0.02; ***p = 0.01.