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Fig. 11 | Molecular Medicine

Fig. 11

From: Characterization of New Polyclonal Antibodies Specific for 40 and 42 Amino Acid-Long Amyloid β Peptides: Their Use to Examine the Cell Biology of Presenilins and the Immunohistochemistry of Sporadic Alzheimer’s Disease and Cerebral Amyloid Angiopathy Cases

Fig. 11

Immunohistochemical analysis of a presenile AD case with typical cerebral amyloid angiopathy by the IgG-purified fractions of FCAs

The cortex of a neuropathologically diagnosed presenile AD case with CAA was incubated with the IgG-purified fractions of FCA18 (A; 1:500 dilution), FCA3340 (B, 1:50 dilution), or FCA3542 (C, 1:50 dilution), and immunoreactivity was revealed by the biotin-streptavidin-peroxidase method. L, leptomen-ingeal arterioles; C, cortical arterioles; black arrow indicates immature plaque, and white arrowheads indicate mature lesions. Magnification: A–C, × 50.

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