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Fig. 2 | Molecular Medicine

Fig. 2

From: Expression of TNF and TNF Receptors (p55 and p75) in the Rat Brain after Focal Cerebral Ischemia

Fig. 2

Double-fluorescent immunohistochemistry showing the colocalization of TNF IR with neuronal (NF200) and glial (GFAP) cell markers

The majority of cells expressing TNF within the ischemic cortex (A, red filter) also showed NF200 IR (B, green filter). However, the dense network of TNF-positive fibers showed a negative correlation with this neuronal marker, suggesting that they represent glial processes. GFAP-positive astrocytes within the hypoperfused penumbra (D, green filter) also show TNF IR (C, red filter).

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