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Fig. 3 | Molecular Medicine

Fig. 3

From: Transcription Factor-Based Drug Design in Anticancer Drug Development

Fig. 3

Targeting transcription factor-DNA binding by “rational” design of small-molecule drugs

A stereo-diagram depicting a representative—dimeric—transcription factor (in red, white, and blue) interacting symmetrically with a DNA double helix (in yellow). Protein contacts to DNA are mediated through a combination of coulombic, polar, and nonpolar interactions with the deoxyribose-phosphate backbone and with the pendant heterocyclic bases (see text for details). Red circles in the interface of the two macromolecules mark potential target sites within the DNA-binding domain of the transcription factor moiety for structure-based or de novo design of small-molecule drugs interfering with its DNA-binding activity.

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