Fig. 1

Cytokine plasma levels following LPS injection in wild-type and LT-α/TNF−α mutant mice

Mice of the three genotypes (8 to 10 for each time point; wild-type mice: white bars; heterozygous mice: gray bars; LT-α/TNF-α−/− mice: black bars) were injected with 100 µg of S. typhimurium LPS and bled 1.5 hr thereafter. The concentration of TNF-α, IL-1α, IL-1β, IL-6, IL-10, and IFN-γ in the plasma were determined with specific immunoassays. Results are presented as the mean and SEM. When relevant, the statistical significance of the differences between genotypes is indicated (*p < 0.05; **p < 0.01 by a t test).