Fig. 4From: Lipopolysaccharide-Induced Cytokine Cascade and Lethality in LTα/TNFα-Deficient Mice Protection by CNI 1493 from LPS-induced lethality Groups of 11 wild-type (A) and LT-α/TNF-α−/− mutants (B) were injected intraperitoneally with the indicated dose of CNI-1493 (▲, 0 mg/kg; ■, 2 mg/kg; ●, 10 mg/kg) 1 hr 30 min before an intravenous injection of 600 µg of S. typhimurium LPS. Lethality was monitored daily for 7 days, no death occurring after day 5.Back to article page