Fig. 2
From: Charcot-Marie-Tooth Disease: Lessons in Genetic Mechanisms
Mariner transposon mediated recombination hot spot. The unequal crossing-over event with the distal CMT1A-REP aligning with homologous proximal CMT1A-REP is shown at the top of the figure; the bottom section shows an enlargement of the recombination hotspot region. The mariner insect transposon-like element (MITE) is depicted with four hypothetical transposase molecules (filled circles) at the ends. The model consist of three parts: (1) trans-acting transposase initiating a double-strand break at MITE, (2) CMT1A-REP providing 24 Kb of ~99% homology for recombination mediated repair, and (3) the hotspot reflecting resolution of the Holliday junction.