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Table 3 Comparison of the phenotype of developing neurons from synapsin I, synapsin II, and synapsin I/II knockout (k.o.) mice

From: Distinct Roles of Synapsin I and Synapsin II during Neuronal Development

 

Synapsin I k.o.

Synapsin II k.o.

Synapsin I/II k.o.

Lamellipodia formation

Normal

Impaired

Normal

Neurite formation

Normal

Impaired

Normal

Axon differentiation

Normal

Impaired

Normal

Synapse formation

Impaired

Impaireda

Impaireda

Cytoskeletal organization

Normal

Impaired

Intermediate

  1. aA 2- to 3-day delay in synapse formation could be attributable, in part, to a corresponding delay in axon formation.
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