Fig. 1
Aβ induces differentiation of monocytes into macrophages. (A) Dose-dependent induction of macrophage differentiation by Aβ 1–42. Monocytes (5 × 105) were incubated for 7 days in the presence of different concentrations of Aβ 1–42, and the adherent macrophage population was estimated using the MTT assay. a, significantly different (p < 0.001) from DMSO control and 0 µl/ml Aβ. (B) Time kinetics of monocyte differentiation into adherent macrophages induced by Aβ 1–42. *, 1.5 µg/ml Aβ, significantly different from 3.0 and 6.0 µg/ml Aβ, p < 0.05.