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Fig. 2 | Molecular Medicine

Fig. 2

From: Frequent N Addition and Clonal Relatedness among Immunoglobulin Lambda Light Chains Expressed in Rheumatoid Arthritis Synovia and PBL, and the Influence of Vλ Gene Segment Utilization on CDR3 Length

Fig. 2

Deduced amino acid sequences of Vλ cDNA clones from RA synovia, RA PBL, and normal PBL. Dots indicate sequence homology; single-letter amino acid abbreviations are used, X, stop codon in deduced amino acid sequence. *, termination of cDNA transcript. ‡, Clone BCSynL32 contains FR1 and CDR1 domains from Vλ gene segment 6S1 and FR2 through CDR3 domains from Vλ gene segment DPL8. §, Clones containing insertions or deletions: ASSynL191 has a three-nucleotide deletion in CDR1, denoted by dash; ASPBLL54 has a two-base pair deletion in FR1; ITPBLL4 has a onenucleotide insertion in the CDR3 interval; ITPBLL75 contains a 10-nucleotide deletion at the FR3-CDR3 junction; LBPBLL4 has a one-nucleotide insertion in DR3; LKPBLL10 contains a one-nucleotide deletion in FR2 and a one-nucleotide insertion (or a two nucleotide deletion) in CDR3; LKPBLL53 has a one-nucleotide insertion (or a two nucleotide deletion) in the CDR3 interval; LKPBLL68 has a three-nucleotide (one codon) insertion in CDR1. ‖, Clone BC-SynL38 contains a stop codon in FR2. Genbank accession numbers for nucleotide sequences are as follows: AS Synovium: AF060120-AF060150; AS PBL: AF058057-AF058078; BC Synovium: AF063714-AF063734; BC PBL: AF063694-AF063713; IT PBL: AF063735-AF063762; LB PBL: AF063765-AF063782; LK PBL: AF064494-AF064513.

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Molecular Medicine

ISSN: 1528-3658