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Fig. 7 | Molecular Medicine

Fig. 7

From: Frequent N Addition and Clonal Relatedness among Immunoglobulin Lambda Light Chains Expressed in Rheumatoid Arthritis Synovia and PBL, and the Influence of Vλ Gene Segment Utilization on CDR3 Length

Fig. 7

(A) CDR3 lengths of Vλ clones from RA synovia, RA PBL, and normal PBL. The proportions of clones with CDR3 intervals of 11 codons (gray segments), 12 codons (black segments) and >12 codons (white bars) are shown. Proportions of clones with <10 codons are not represented. (B) Mean CDR3 lengths of clones according to the length of the germline component of the Vλ gene segment utilized. Germline gene segments are grouped into those with 29 nucleotides (white bars), 24 nucleotides (gray bars), and 23 nucleotides (black bars). Clones with out-of-frame CDR3 intervals (see Fig. 3) were not included.

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Molecular Medicine

ISSN: 1528-3658