Skip to main content
Fig. 8 | Molecular Medicine

Fig. 8

From: Frequent N Addition and Clonal Relatedness among Immunoglobulin Lambda Light Chains Expressed in Rheumatoid Arthritis Synovia and PBL, and the Influence of Vλ Gene Segment Utilization on CDR3 Length

Fig. 8

Nucleotide sequences that may be the result of oligoclonal B-cell expansion, defined as utilizing the same V and J gene segments with shared mutations and having identical CDR3 lengths. Only codons for which there are differences from the corresponding germline gene segment are shown. Dots denote nucleotide homology. Shared nucleotide changes are shown as shaded boxes, with changes that may represent possible allelic variations (see Table 2) underlined. Palindromic (P) nucleotides are shown in lower case. (A) IGLV3S2-derived clones from synovium of RA patient AS. (B) hsiggll150-derived clones from synovium of RA patient AS. (C) hsiggll150-derived clones from PBL of RA patient AS. (D) hsiggll150-derived clones from synovium of RA patient BC. (E) VλIII.1-derived clones from PBL of RA patient BC. (F) hsiggll150-derived clones from the PBL of normal individual LK.

Back to article page