Table 1A Germline derivation of V λ gene segments in cDNA clones from patients with rheumatoid arthritis and normal controls
Vλ Family | VλI | VλIIIa | VλIIIb | VλIIIc | VλIV | VλV | VλVI | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene Segment | lv1042 | DPL6 | 3S2 | lv318 | 2–14 | 150 | 3a | 3p | 2–19 | III.1 | 8A1 | lv801 | 5-4 | 5a | 5c1 | 5c2 | 4-2 | 6S1 | Total | |
RA | AS Synovium | 1 | 1 | 5 | 3 | 0 | 10 | 0 | 1 | 1 | 5 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 31 |
AS PBL | 3 | 0 | 1 | 4 | 0 | 8 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 22 | |
BC Synovium | 1 | 0 | 4 | 0 | 1 | 4 | 0 | 4 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 21 | |
BC PBL | 0 | 0 | 1 | 0 | 2 | 1 | 0 | 5 | 0 | 6 | 0 | 0 | 0 | 1 | 0 | 2 | 1 | 1 | 20 | |
Normal | LB PBL | 1 | 0 | 0 | 0 | 3 | 6 | 0 | 0 | 0 | 3 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 2 | 18 |
IT PBL | 0 | 0 | 1 | 0 | 5 | 11 | 1 | 0 | 0 | 7 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 29 | |
LK PBL | 2 | 0 | 0 | 0 | 0 | 6 | 0 | 1 | 1 | 7 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 20 | |
Total | 8 | 1 | 12 | 7 | 11 | 46 | 1 | 11 | 2 | 36 | 4 | 1 | 2 | 2 | 2 | 5 | 1 | 9 | 161 | |