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Table 1B Germline derivation of unrearranged V λ gene segments amplified from genomic DNA of rheumatoid arthritis patient BC and normal control LB

From: Frequent N Addition and Clonal Relatedness among Immunoglobulin Lambda Light Chains Expressed in Rheumatoid Arthritis Synovia and PBL, and the Influence of Vλ Gene Segment Utilization on CDR3 Length

 

Vλ, Family

VλIIIa

VλIIIb

VλIIIc

 

PBL

Gene Segment

3i

150

3a

3p

III.1

3e

Total

RA

BC

3

3

0

3

6

1

16

Normal

LB

1

2

1

3

8

2

17

 

Total

4

5

1

6

14

3

33

  1. All but two genomic sequences in Table 1B were 100% identical to reported sequences of corresponding germline gene segments (Genbank Accession numbers: LBLG9-AF063764; LBLG14; AF063763). Mismatches in number of clones analyzed in Tables 1A and 1B are attributable to truncated sequences.
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Molecular Medicine

ISSN: 1528-3658