Skip to main content

Table 3 N region and CDR3 lengths of immunoglobulin V λ and V κ clones from RA synovia and PBL and normal PBL

From: Frequent N Addition and Clonal Relatedness among Immunoglobulin Lambda Light Chains Expressed in Rheumatoid Arthritis Synovia and PBL, and the Influence of Vλ Gene Segment Utilization on CDR3 Length

 

Vλ

Tissue

No. Clones

P

N

Mean

Mean CDR3

No. Clones

P

N

Mean

Mean CDR3

Sample

Analyzed

Addition

Addition

No. N’s*

Length

Analyzed

Addition

Addition

No. N’s

Length

AS Syn

30

13.3%

50.0%

3.3 ± 6.1

10.5 ± 1.4

11

27.2.%

54.5%

1.7 ± 1.2

9.8±1.0

AS PBL

20

30.0%

45.0%

2.4 ± 1.1

10.7 ±1.3

10

20.0%

60.0%

1.7 ± 1.2

9.9 ± 0.9

BC Syn

21

33.3%

42.8%

1.9 ± 1.1

10.5 ± 1.1

14

35.7%

57.1%

1.8 ± 1.0

9.5 ± 1.2

BC PBL

20

10.0%

40.0%

3.0 ± 1.3

10.3 ± 1.0

15

33.3%

60.0%

1.9 ± 2.3

9.3 ± 1.0

LB PBL

18

16.7%

33.3%

2.5 ± 1.4

9.9 ± 1.1

12

25.0%

16.7%

3.0 ± 2.8

9.1 ± 0.5

LK PBL

19

15.8%

26.3%

2.6 ± 1.3

9.7 ± 1.6

11

18.1%

45.5%

3.8 ± 4.1

9.5 ±0.7

IT PBL

28

32.1%

42.9%

2.2 ± 1.6

10.4 ± 1.1

11

18.1%

18.1%

2.0 ± 1.4

9.0 ± 0.6

  1. Vκ data are derived from (16).
  2. P addition and N addition refer to the percentage of clones containing at least one palindromic nucleotide or nucleotide of N-region addition, respectively. Mean number of nucleotides and CDR3 lengths (expressed as number of amino acid codons) are shown ± one standard deviation.
  3. * The mean number of nucleotides refers to the average number of nucleotides added among the clones that contain N-region addition.