Fig. 6

Bilateral and unilateral renal agenesis in Fmn exon 4- and exon 5-deficient mice. These photographs of the retroperitoneal area of neonatal fmn^4KO/fmn^4KO and fmn^5KO/fmn^5KO animals illustrate the bilateral and unilateral renal agenesis phenotype seen in these mice at the incidence rates presented in Table 1. Organs contained within the peritoneum that obscured the view of the kidney region were removed prior to photographing. The adrenal glands (at level of white arrows), which are located near the top pole of the kidney, were always present bilaterally. (A) fmn^4KO/fmn^4KO animal with bilateral renal agenesis. (B) fmn^4KO/fmn^4KO littermate animal with normal two kidneys (for comparison). (C) fmn^3KO/fmn^5KO animal with unilateral renal agenesis. (D) fmn^5KO/fmn^5KO littermate animal with normal two kidneys (for comparison).