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Table 1 Incidence of renal aplasia in newborn fmn 4KO and fmn 5KO homozygous mice

From: The Mouse formin (Fmn) Gene: Abundant Circular RNA Transcripts and Gene-Targeted Deletion Analysis

Genotype a

Total Animals

Number of Kidneys

 

Total Abnormal (%)

2

1

0

fmn4KO/fmn4KO

115

130

9

12

13.9

fmn5KO/fmn5KO

249

246

3

0

1.2

 

(167 + 82)b

(165 + 81)b

(2 + 1)b

0

(1.2 and 1.2)b

Background controls

     

fmn4KO/+

112

112

0

0

0

fmn5KO/+

253

253

0

0

0

+/+

255

255

0

0

0

  1. aThe listed genotypes were derived from matings of homozygous animals. Newborns were sacrificed within 24 hr of birth.
  2. bNumbers in parentheses are the breakdown data from two fmn3KO/fmn5KO mouse lines derived from two independently derived targeted ES cell clones (clones 6 and 15, respectively).