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Table 2 Genotype frequencies of polymorphisms at positions −238 and −376 in a group of 403 healthy individuals

From: Functional Analysis of a Human Tumor Necrosis Factor α (TNF-α) Promoter Polymorphism Related to Joint Damage in Rheumatoid Arthritis

 

TNF Polymorphism

 

−238

−376

Allele Frequencies (%)

  

Genotypes

GG

GA

GG

GA

-238A

-376A

-238GAa and -376GA (%)

-376GAb and -238GA (%)

Healthy individuals (n = 403) (%)

370 (91.8)

33 (8.2)

399 (99.0)

4 (1.0)

4.1

0.5

12.1

 
  1. Delta-value for linkage disequilibrium (Δ = 0.342, p < 0.001) was defined according to the maximum likelihood procedure, with the iterative process outlined by Hill (27).
  2. aPercentage of -238GA genotyped individuals who also have a -376GA genotype.
  3. bPercentage of -376GA genotyped individuals who also have a -238GA genotype.
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Molecular Medicine

ISSN: 1528-3658