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Table 2 Genotype frequencies of polymorphisms at positions −238 and −376 in a group of 403 healthy individuals

From: Functional Analysis of a Human Tumor Necrosis Factor α (TNF-α) Promoter Polymorphism Related to Joint Damage in Rheumatoid Arthritis

  TNF Polymorphism
  −238 −376 Allele Frequencies (%)   
Genotypes GG GA GG GA -238A -376A -238GAa and -376GA (%) -376GAb and -238GA (%)
Healthy individuals (n = 403) (%) 370 (91.8) 33 (8.2) 399 (99.0) 4 (1.0) 4.1 0.5 12.1  
  1. Delta-value for linkage disequilibrium (Δ = 0.342, p < 0.001) was defined according to the maximum likelihood procedure, with the iterative process outlined by Hill (27).
  2. aPercentage of -238GA genotyped individuals who also have a -376GA genotype.
  3. bPercentage of -376GA genotyped individuals who also have a -238GA genotype.