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Fig. 3 | Molecular Medicine

Fig. 3

From: Sequence Polymorphism in Two Novel Plasmodium vivax Ookinete Surface Proteins, Pvs25 and Pvs28, That Are Malaria Transmission-blocking Vaccine Candidates

Fig. 3

Presumed schematic representation of mutation hot spots in an EGF-like domain of zygote/ookinete surface proteins of malaria parasite. Cysteine bridges between first (C1) and third (C3), second (C2) and fourth (C4), and fifth (C5) and sixth (C6) cysteine residues in each domain are indicated by bars. The positions of the amino acid substitution are indicated in the schema. The positions of amino acid substitutions obtained from the ookinete surface proteins of Plasmodium falciparum are derived from previously published data on Pfs25 (22,23) and Pfs28 (24). Region I designates the amino acid sequences upstream of Cys1 in each domain. Regions II, III, IV, V, and VI designate the amino acid sequences between Cysl and Cys2, Cys2 and Cys3, Cys3 and Cys4, Cys4 and Cys5, and Cys5 and Cys6 in each domain, respectively. Region VII designates the amino acid sequences downstream of C6 in each domain. Loops are designated A, B, and C.

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Molecular Medicine

ISSN: 1528-3658