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Scheme 1 | Molecular Medicine

Scheme 1

From: Immunological Evidence that Non-carboxymethyllysine Advanced Glycation End-products Are Produced from Short Chain Sugars and Dicarbonyl Compounds in vivo

Scheme 1

Possible routes of AGE formation.

Advanced glycation end-products (AGE) arise from the decomposition of Amadori products (AGE-1), the glycolysis intermediate product glyceraldehyde (AGE-2), the Schiff base fragmentation product glycolaldehyde (AGE-3), the glyceraldehyde and the Amadori product fragmentation product methylglyoxal (AGE-4), and the autoxidation of glucose to glyoxal (AGE-5). CEL, N-(carboxyethyl)lysine; CML, N-(carboxymethyl)lysine.

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Molecular Medicine

ISSN: 1528-3658