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Table 1 Effect of TNFbp treatment on renal injury in anti-GBM disease

From: TNF-α Up-regulates Renal MIF Expression in Rat Crescentic Glomerulonephritis

 

Proteinuria (mg/24 hr)

Serum Creatinine (µmol/L)

Glomerular Hypercellularity (0–3)

Glomerular Crescents (%)

Interstitial Fibrosis (0–4)

Normal

9 ± 2

42.7 ± 1.0

0

0

0

Saline treated

     

Day 1

65 ± 22a

47.8 ± 6.0

0.82 ± 0.10

0

0.8 ± 0.2

Day 7

204 ± 22c

59.3 ± 4.4b

1.30 ± 0.17

10.3 ± 2.1

2.3 ± 0.3

Day 14

288 ± 14c

67.2 ± 2.4c

1.40 ± 0.06

17.3 ± 2.6

3.2 ± 0.3

TNFbp treated

     

Day 1

43 ± 4a

49.0 ± 4.4

0.71 ± 0.07

0.3 ± 0.3

0.5 ± 0.2

Day 7

125 ± 18c,f

47.2 ± 5.1

0.99 ± 0.12

0.3 ± 0.2f

1.2 ± 0.2d

Day 14

190 ± 16c,f

46.0 ± 1.8e

0.89 ± 0.07e

0.9 ± 0.3f

1.2 ± 0.2e

  1. Data shown as mean ± SEM. ap < 0.05, bp < 0.01; cp < 0.001 versus normal; dp < 0.05; ep < 0.01, fp < 0.001 compared to time-matched saline-treated animals.