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Table 1 Effect of TNFbp treatment on renal injury in anti-GBM disease

From: TNF-α Up-regulates Renal MIF Expression in Rat Crescentic Glomerulonephritis

  Proteinuria (mg/24 hr) Serum Creatinine (µmol/L) Glomerular Hypercellularity (0–3) Glomerular Crescents (%) Interstitial Fibrosis (0–4)
Normal 9 ± 2 42.7 ± 1.0 0 0 0
Saline treated      
Day 1 65 ± 22a 47.8 ± 6.0 0.82 ± 0.10 0 0.8 ± 0.2
Day 7 204 ± 22c 59.3 ± 4.4b 1.30 ± 0.17 10.3 ± 2.1 2.3 ± 0.3
Day 14 288 ± 14c 67.2 ± 2.4c 1.40 ± 0.06 17.3 ± 2.6 3.2 ± 0.3
TNFbp treated      
Day 1 43 ± 4a 49.0 ± 4.4 0.71 ± 0.07 0.3 ± 0.3 0.5 ± 0.2
Day 7 125 ± 18c,f 47.2 ± 5.1 0.99 ± 0.12 0.3 ± 0.2f 1.2 ± 0.2d
Day 14 190 ± 16c,f 46.0 ± 1.8e 0.89 ± 0.07e 0.9 ± 0.3f 1.2 ± 0.2e
  1. Data shown as mean ± SEM. ap < 0.05, bp < 0.01; cp < 0.001 versus normal; dp < 0.05; ep < 0.01, fp < 0.001 compared to time-matched saline-treated animals.