Table 1 Effective concentrations of phospholipase C and endocytosis inhibitors, and lysomotrophic amines in suppressing type II NOS production by human and mouse cells
Cells Tested | ||
|---|---|---|
Inhibitor | A549 | RAW 264.7 |
Phospholipase C inhibitors | ED50a | |
D609 | 18 µg/ml | 25 µg/ml |
U73122 | 8 µM | 6 µM |
Neomycin sulfate | 14 mM | 13 mM |
NCDC | 64 µM | 108 µM |
Endocytosis and lysomotrophic amines | ||
Rotenone | 0.2 µM | 50 µM |
Oligomycin | 0.5 µg/ml | 0.5 µg/ml |
Antimycin | 0.1 µM | 130 µM |
Monensin | 10 µM | 38 µM |
Ammonium chloride | 17 µM | 50 µM |
Colchicine | 100 µM | 200 µM |