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Fig. 1 | Molecular Medicine

Fig. 1

From: Imbalanced Distribution of Plasmodium falciparum MSP-1 Genotypes Related to Sickle-Cell Trait

Fig. 1

Frequency of the MSP-1 allelic families in the cohort recruited in Dielmo, Senegal, unstratified (total), and stratified by age, hemoglobin type and presence (+) or absence (−) of the HLA Bw53 allele

Distribution of the various factors investigated was as follows: among the ≤10 year-olds, there were 19 AA (4 Bw53+, 14 Bw53−, and one individual untyped for this locus) and 7 AS children (1 Bw53+, 4 Bw53−, and 2 children untyped for this locus). The AA group (19 ≤ 10 years and 38 > 10 years) contained 17 Bw53+, 33 Bw53−, and 7 individuals untyped for this locus. The AS group (7 ≤ 10 years and 13 > 10 years) contained 5 Bw53+, 12 Bw53−, and 3 subjects untyped for this locus. The Bw53+ group contained 4 ≤ 10 years and 18 > 10 years, 17 AA and 5 AS subjects. The group of subjects not harboring the Bw53 allele contained 19 ≤ 10 years and 26 > 10 years, 33 AA and 12 AS subjects. Typing of the parasites was done as described in Materials and Methods. Assignment of a PCR fragment to a specific allelic family was done by hybridization using family-specific probes under distinct conditions of stringency and verified by secondary nested PCR using family-specific primers.

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