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Table 2 Distribution of individual MSP-1 and MSP-2 alleles by age, hemoglobin type, or HLA Bw53 type in the cohort recruited in Dielmo, Senegal

From: Imbalanced Distribution of Plasmodium falciparum MSP-1 Genotypes Related to Sickle-Cell Trait

 

MSP-1 Genotyping

MSP-2 Genotyping

   

No. of Subjects Positive for Each Individual Allele

 

No. of Subjects Positive for Each Individual Allele

   

K1

MAD20

RO33

  

3D7

FC27

Hybrids

 

No. PCR+

Total No. of Bands

a

b

c

d

e

f

g

h

a

b

c

d

e

a

b

c

d

No. PCR +

Total No. of Bands

a

b

c

d

e

f

g

h

A

B

C

D

E

F

G

a′

b′

c′

d′

e′

f′

g′

   

390

380

300

290

250

230

220

200

390

300

290

230

220

390

250

230

220

  

700

650

640

630

600

580

510

450

650

640

600

550

510

480

450

650

640

600

510

500

450

430

Total

67

224

8

1

7

30

8

11

28

8

3

9

1

22

33

4

1

21

29

60

179

1

9

10

1

25

1

17

3

8

16

24

4

24

1

16

3

2

5

5

1

2

1

≤10 years

24

106

4

1

64

8

3

9

6

3

3

8

1

13

6

3

0

17

17

23

93

0

3

7

1

14

1

10

0

3

9

11

1

12

1

10

2

0

3

1

1

2

1

>10 years

43

118

4

0

3

22

5

2

22

5

0

1

0

9

27

1

1

4

12

37

86

1

6

3

0

11

0

7

3

5

7

13

3

12

0

6

1

2

2

4

0

0

0

AS

14

47

1

1

0

0

8

0

2

8

0

0

0

5

4

4

1

6

7

15

33

1

0

0

0

2

0

3

1

0

2

5

4

6

1

4

0

1

1

2

0

0

0

AA

53

177

7

0

7

30

0

11

26

0

3

9

1

17

29

0

0

15

22

45

146

0

9

10

1

23

1

14

2

8

14

19

0

18

0

12

3

1

4

3

1

2

1

Bw53+

19

59

2

0

3

7

3

4

8

1

0

2

0

7

10

0

0

4

8

14

38

0

2

2

0

5

1

2

0

1

8

3

1

5

0

5

1

0

0

2

0

0

0

Bw53−

41

138

6

1

4

19

4

6

17

6

2

5

1

14

18

3

1

14

17

38

125

1

7

7

I

15

0

13

3

7

7

20

3

17

1

9

2

1

4

3

1

2

1

  1. No. PCR+ refers to the number of individuals who had a positive PCR for the locus considered. Total No. of bands refers to the sum of PCR fragments detected in all samples for the locus considered. Individual MSP-1 and MSP-2 alleles were identified as indicated in Materials and Methods. Arbitrary codes were given to individual alleles within each allelic family. The size of the alleles (in bp) is indicated below the code. For each individual allele, the number of samples in which this allele has been detected is indicated. Statistically significant differences in allele frequency (calculated as number of samples in which this allele has been detected divided by total number of fragments for that locus) are indicated in boxes.